Creatinine is a naturally occurring amino acid (protein building block) found mainly in muscles. When muscle cells decompose, it results in the generation of Creatinine as a waste product. During Creatinine supplementation, the body's Creatinine levels can rise and this might be due to a result of increased muscle growth or exercises.

Creatinine supplements help lowering the levels of blood lipids (cholesterol) in patients with unnaturally high concentrations of lipids in the bloodstream, and this linkage defines the biological association between Creatinine level and hypertension. Regulation of cholesterol in the body lowers hypertension. A few clinical studies have shown that many people who suffered from heart failure took Creatinine supplements, and had a noteworthy enhancement in symptoms and exercising capacity when compared to subjects who received placebo. A clinical study limited to twenty patients with heart failure discovered that short-term Creatinine supplementation plus standard prescribed medications leads to an overall increase of body weight and improve the strength of the muscle.

Before taking Creatinine supplements, patients should be aware of drug interactions. Creatinine supplementation can cause kidney damage when taken with cimetidine, non-steroidal anti-inflammatories, probenecid and diuretics.

Creatinine, combined with ephedra, caffeine, or other substances which can stimulate the body's central nervous system, can cause strokes. Also, Creatinine supplements should not be taken by anyone with a history of high blood pressure, kidney problems or liver disease.