The very initial treatment with Apresoline injection begins with the administration of 5mg-10 mg of the drug. This lower concentration is intentionally prescribed so as to prevent the chances of extreme arterial pressure. After an interval of 20-30 minutes, the response of the person to the given dosage is examined. Based on the response or percentage of improvement, the same dosage may be repeated if necessary. However, before the administration of the second dose, the person is thoroughly monitored for examining any changes in the heart beat rate as well as the blood pressure. Ideally, after the injection of the drug, the person should record the blood pressure around 90/100 mmHg. The right way of injecting this strong drug is to dilute it first in 1 ml of water. The solution obtained must be further diluted with around 10 ml of sodium chloride. This final solution is designed for slow intravenous administration. Once the desired dosage of the drug is injected the rest of the remaining solution should be immediately discarded.
The drug is also licensed for continuous intravenous infusion with an ideal flow rate of 200-300 ug/min. To proceed with this treatment method, dry powdered form of the drug should be essentially dissolved in 1 ml of water.

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